李素华课题组

Li Suhua Lab

　　课题组长

李素华，研究员，博士生导师。2017年于清华大学获得博士学位，2017-2020年在德国马克斯·普朗克化学生态所进行博士后研究。长期从事植物激素信号传导和次生代谢调控研究。共发表SCI收录论文10余篇。以第一作者或通讯作者（含共同）在Nature、Molecular Plant、PLoS Biology、Plant Physiology、Plant Journal等国际高水平杂志共发表论文7篇。获得过德国洪堡基金项目资助，获得多项国家和省市级科研项目资助。联系方式：lisuhua01@caas.cn （本实验室长期招聘多组学生物信息分析、植物抗虫机制方向博士后）。

 

　　工作经历

　　2020.6 - 至今       中国农科院深圳农业基因组研究所      研究员

　　2017.4 - 2020.06     德国马普化学生态所                      博士后

 

　　教育经历

　　2010.9 - 2017.1      清华大学          博士

　　2006.9 - 2010.9      中国农业大学   学士

 

　　研究方向

植物和昆虫是组成陆地生态系统的重要组成部分。本课题组利用多组学分析，结合分子生物学、遗传学手段，研究马铃薯、烟草等植物与害虫以及其他生物的互作机制，解析互作中植物激素调控作用，挖掘抗性基因和次生代谢物，为作物抗性育种提供新基因资源。

 

　　研究进展　

该课题组长期从事期从事植物激素和作物抗虫研究，与合作者共同揭示了新型植物激素独脚金内酯的受体感知和信号传导机制。并进一步对其生物学功能进行了研究，发现了独脚金内酯通过和其他多种激素互作来共同调控多种植物代谢物的含量，从而促进植物抵御虫害，响应逆境胁迫的重要功能。且开发了多种新型独脚金内酯和茉莉素相关的高活性人工合成分子，具有较高的潜在农业应用价值。

 

　　PI

Suhua Li, Principle Investigator. She received her Ph.D. degree in Biology from Tsinghua University in 2017. She subsequently worked as a postdoctoral researcher at Max Planck Institute for Chemical Ecology in Germany. She mainly focuses on exploring the function and the molecular mechanism of the transduction of plant hormones, as well as the regulatory mechanism of plant hormones on secondary metabolites. As the first author or co-author, she has published more than 10 papers in research journals such as Nature, Molecular Plant, PLoS Biology, Plant Physiology. She was awarded as an alumni member of Alexander von Humboldt Foundation. Email address: lisuhua01@caas.cn.

　　Working Experience

　　2020.6 – present     Agricultural Genomics Institute at Shenzhen - CAAS         Principal Investigator

　　2017.4 - 2020.6    Max Planck Institute for Chemical Ecology          Postdoctor

 

　　Education

　　2010.9 - 2017.1      Tsinghua University                                                                 PhD

　　2006.9 – 2010.7      China Agricultural University                                                 Bachelor       

 

　　Research Interest

Plants and insects are important components of terrestrial ecosystems. By taking advantage of genomics, metabolomics with genetic methods, our group focuses on the interaction of plant with insects, such as the defense mechanism of potatoes and tobacco, the biosynthesis of secondary metabolites, identify more resistance genes and metabolites, to provide more genetic resources to potato breeding.　　

 

　　Major Achievements

The group leader has worked on plant hormones and insect resistance for a long time. We focused on two kinds of plant hormones, jasmonates and strigolactones, to reveal the molecular mechanisms of their signal transduction, and to investigate their regulatory functions on plant secondary metabolites. Together with collaborators, we revealed the perception mechanism of strigolactones with the receptors and the structure-activity relationships of strigolactones. We further investigated the ecological and physiological functions of strigolactones, such as regulating herbivore defense via manipulating defensive metabolites. In addition, we designed a serious of highly active jasmonate- and strigolactone-analogs, which are with potential possibility of agricultural applications.

 

　　Selected Publication

1.Ziqi Ye, Ruirui Lu, Chao Li, Doudou Yang, Zhuozhen Zeng, Weichao Lin, Jie Cheng, Zhongmin Yang, Li Wang, Yulin Gao, Sanwen Huang, Xingtan Zhang?, Suhua Li?. Haplotype-resolved and chromosome-level genome assembly of Colorado potato beetle. Journal of Genetics and Genomics, 2023, S1673-8527(23)00092-9.

2.Suhua Li *, Yuwen Li*, Linhai Li*, Chi Zhang, Fei Wang, Haiou Li, Ming Wang, Yupei Wang, Fajun Nan, Daoxin Xie, Jianbin Yan. Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development. Plant Journal, 2021, 107, 67–76.

3. Yuwen Li*, Suhua Li *?, Ran Du, Jiaojiao Wang, Haiou Li, Daoxin Xie?, and Jianbin  Yan?. Isoleucine enhances plant resistance against Botrytis cinerea via jasmonate signaling pathway. Frontiers in Plant Science, 2021, 12:628328.

4.  Suhua Li, Youngsung Joo, Dechang Cao, Ran Li, Gisuk Lee, Rayko Halitschke, Gundega Baldwin, Ian T. Baldwin and Ming Wang. Strigolactone signaling regulates specialized metabolism in tobacco stems and interactions with stem-feeding herbivores. PLoS Biology, 2020, 18(8): e3000830.

5.  Ruifeng Yao*, Zhenhua Ming*, Liming Yan*, Suhua Li*, Fei Wang, Sui Ma, Caiting Yu, Mai Yang, Li Chen, Linhai Chen, Yuwen Li, Chun Yan, Di Miao, Zhongyuan Sun, Jianbin Yan, Yuna Sun, Lei Wang, Jinfang Chu, Shilong Fan, Wei He, Haiteng Deng, Fajun Nan, Jiayang Li, Zihe Rao, Zhiyong Lou, Daoxin Xie. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 2016, 536: 469-473.

6.  Suhua Li*, Linhai Chen*, Yuwen Li, Ruifeng Yao, Fei Wang, Mai Yang, Min Gu, Fajun Nan, Daoxin Xie, Jianbin Yan. Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 2016, 10(9): 1432-1435.

7. Jianbin Yan*, Suhua Li*, Min Gu, Ruifeng Yao, Yuwen Li, Juan Chen, Mai Yang, Jianhua Tong, Langtao Xiao, Fajun Nan, Daoxin Xie. Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 2016, 172(4): 2154-2164.

8. Ming Wang, Martin Sch?fer, Dapeng Li, Rayko Halitschke, Dong Chuanfu, Erica McGale, Christian Paetz, Yuanyuan Song, Suhua Li, Junfu Dong, Sven Heiling, Karin Groten, Philipp Franken, Michael Bitterlich, Maria J Harrison, Uta Paszkowski, Ian T Baldwin. Blumenols as shoot markers of root symbiosis with arbuscular mycorrhizal fungi. eLife, 2018, 7:e37093.

9.  Jianbin Yan, Ruifeng Yao, Li Chen, Suhua Li, Min Gu, Fajun Nan, Daoxin Xie. Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant, 2018, 11: 1237-1247.

10. Ruifeng Yao, Lei Wang, Yuwen Li, Li Chen, Suhua Li, Xiaoxi Du, Bing Wang, Jianbin Yan, Jiayang Li, Daoxin Xie. Rice DWARF14 acts as an unconventional hormone receptor for strigolactone. Journal of Experimental Botany, 2018, 69: 2355-2365.

11.  Haiou Li, Ruifeng Yao, Sui Ma, Shuai Hu, Suhua Li, Yupei Wang, Chun Yan, Daoxin Xie, Jianbin Yan. Efficient ASK-assisted system for expression and purification of plant F-box proteins. The Plant Journal, 2017, 92(4): 736-743.

12.  Jianbin Yan, Haiou Li, Suhua Li, Ruifeng Yao, Haiteng Deng, Qi Xie, Daoxin Xie. The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCF^COI1 and degraded via the 26S proteasome pathway. The Plant Cell, 2013, 25: 486-498.

       *Co-first author, #Corresponding author

　　李素华课题组更新于2023年7月