陈凯园课题组

Chen Kaiyuan Lab

chenkaiyuan@caas.cn

课题组长

陈凯园，所聘副研究员（Pre-PI），硕士生导师。2021年博士毕业于华中农业大学。主要从事植物CRISPR基因组编辑技术的开发以及在分子育种中的应用。以第一作者或共同一作在Molecular Plant期刊发表论文2篇，获国家发明专利2项。

工作经历

2022/06 – 至今 中国农业科学院农业基因组研究所  副研究员

2022/06 – 至今 中国农业科学院农业基因组研究所  博士后

教育经历

2013/09 – 2021/06 华中农业大学  植物病理学 博士

2009/09 – 2013/06 华中农业大学楚天学院    生物工程 学士

研究方向

(1) 围绕“优薯计划”，利用基因组编辑技术创制马铃薯雄性不育系，助力二倍体马铃薯杂交育种。

(2) 结合基因组编辑技术，探索可固定杂种优势的育种策略。

(3) 在植物中开发并优化基于CRISPR系统的遗传操作技术。

Chen Kaiyuan, Pre-PI, Master Advisor, received the Ph.D. degree from Huazhong Agricultural University in 2021. His research focuses on the improvement of plant CRISPR genome editing technologies and their applications in molecular breeding. He has published two papers in Molecular Plant as the first author or co-first author, and obtained two invention patents.

Working Experience

2022/06 – Present  Agricultural Genomics Institute at Shenzhen - CAAS    Pre-PI

2022/06 – Present  Agricultural Genomics Institute at Shenzhen - CAAS    Postdoctoral Fellow

Education

2013/09 – 2021/06  Huazhong Agricultural University                   Plant Pathology    Ph.D.

2009/09 – 2013/06  Huazhong Agricultural University Chutian College   Bioengineering    Bachelor

Research Interest

(1) Creating genic male-sterility potatoes for diploid potato hybrid breeding by CRISPR technologies.

(2) Exploring breeding strategies for fixing heterosis by genome editing technologies.

(3) Developing and optimizing CRISPR-based technologies for the manipulation of plant genomes.

Selected Publication

1. Kaiyuan Chen, Runnan Ke, Manman Du, Yuqing Yi, Yache Chen, Xiaochun Wang, Lu Yao, Xin Hou, Lizhong Xiong, Yinong Yang, and Kabin Xie. A FLASH pipeline for arrayed CRISPR library construction and function discovery of Receptor-Like-Kinases in rice. Molecular Plant, 2022, 15(2):243-257  

2. Dan Ding#, Kaiyuan Chen#, Yuedan Chen, Hong Li, and Kabin Xie. Engineering Introns to Express RNA Guides for Cas9- and Cpf1-Mediated Multiplex Genome Editing. Molecular Plant, 2018, 11(4):542-552 （#Equal contributions; Best of Molecular Plant 2018）

3. Kaiyuan Chen, Hao Liu, Muhammad Tahir ul Qamar, Kabin Xie, Ling-Ling Chen. Advances in guide RNA design for editing plant genomes using CRISPR-Cas systems. In: Willmann, M. R. (ed.), Genome editing for precision crop breeding, Burleigh Dodds Science Publishing, Cambridge, UK, 2021. (Book Chapter )  

Patent

1. 谢卡斌，陈凯园，丁丹.  一种基于CRISPR系统的基因组编辑方法及其应用.  专利号：ZL201711194336.6

2. 谢卡斌，陈凯园.  一种高通量的基因编辑方法.  专利号：ZL202010772166.0