导师简介

唐中林，博士，研究员，博士生导师。中国农业科学院“猪基因组设计育种创新团队”首席科学家，中国农业科学院佛山鲲鹏现代农业研究院执行院长。2006-2017年在中国农业科学院北京畜牧兽医研究所任副研究员、研究员，2015-2016年在哈佛大学医学院做访问学者，2018年12月-2021年5月受聘为中国农业科学院深圳农业基因组研究所动物基因组研究中心主任。

2014年入选科技部“创新人才推进计划”领军人才，2016年入选国家重大人才工程科技创新领军人才。目前兼任国际PAG-Asia会议共同主席、中国畜牧兽医学会动物遗传育种分会理事、中国畜牧兽医学会养猪分会理事、中国畜牧兽医学会畜禽遗传标记分会常务理事和中国实验动物学会第一届无菌动物专业委员会常务委员、全国生猪遗传改良计划专家委员会委员（2021-2035）、第三次全国畜禽遗传资源普查技术专家组成员、“农业部猪肉质量安全控制重点实验室”学术委员会副主任、“广西壮族自治区巴马香猪资源开发工程研究中心”主任、“广西家畜遗传改良重点实验室”学术委员会副主任，《Frontiers in bioscience》、《Genes》、《Animals》等多种国际刊物和《中国实验动物学报》编委，《中国比较医学杂志》通讯编委。此外，受聘为华中农业大学、华南农业大学、广西大学、河南大学等国内多个高校的兼职教授，荷兰瓦赫宁根大学、新西兰都柏林大学和澳大利亚默多克大学等多个国外大学的博士生联合导师。主持国家自然科学基金重点及面上项目、973子课题、863重点和转基因重大专项子课题、广东省重点研发项目、广东省粤深联合基金重点项目、中国农科院重大科研任务等国家及省部级项目近20项；发表科研论文143篇（其中SCI论文70篇），其中以第一作者或通讯作者（含共同）在Genome Biology、Nucleic Acid Research、JBC和DNA Research等国际知名刊物发表SCI论文40余篇，论文被SCI引用1037次，受国外学者邀请参编专著3本。作为主要完成人获国家技术发明二等奖、中国发明专利银奖、中国专利优秀奖、广西科技进步二等和三等奖、中华农业科技奖优秀创新团队奖等国家和省部级奖7项，中国科协优秀论文特等奖1项，获国际发明专利1项，国家发明专利18项，软件著作权23项，实用新型专利1项，作为主要完成人培育猪新品种和配套系3个。

团队简介

猪基因组设计育种创新团队专注于功能基因组与基因组设计育种相关研究。主要包括：综合利用高通量的基因组、转录组、代谢组、蛋白组等多种组学技术和精准基因编辑技术，解析猪和小鼠等动物组织器官生长发育、产肉性状、营养利用和抗病等重要经济性状形成的分子机制；利用生物信息、分子和细胞生物学等手段，在分子、细胞和个体水平，阐明基因和非编码RNA的功能和表达调控机制；整合多组学数据和全基因组关联分析，大规模挖掘猪等动物经济性状关键基因和新的遗传标记；开发猪全基因组设计育种的新理论新方法，开展猪育种新材料创制和品种改良。

研究成果

1.Adeyinka A. Adetula, Xinhao Fan, Yongsheng Zhang, Yilong Yao, Junyu Yan, Muya Chen, Yijie Tang, Yuwen Liu, Guoqiang Yi, Kui Li & Zhonglin Tang (2021) Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (Sus-scrofa), RNA Biology, DOI: 10.1080/15476286.2021.1954380

2.Yan J, Yang Y, Fan X, Tang Y, Tang Z*. Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7. Genes (Basel). 2021 May 8;12(5):696. doi: 10.3390/genes12050696.

3.Yalan Yang#, Xinhao Fan#, Junyu Yan#, Muya Chen, Min Zhu, Yijie Tang, Siyuan Liu, Zhonglin Tang*. A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development. Nucleic Acids Research. 2020, 49(3):1313-1329

4.Zhou, C.*, Sun, Y.*, Yan, R.*, Liu, Y.*, Zuo, E.*, Gu, C., Han, L., Wei, Y., Hu, X., Zeng, R., Li, Y.#, Zhou, H.#, Guo, F.#, Yang, H.# .(2019).Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis. Nature:571, 275–278

5.Zuo, E.*, Sun, Y.*, Wei, W.*, Yuan, T.*, Ying, W., Sun, H., Yuan, L., Steinmetz, L. M.#, Li, Y.#, Yang, H#.(2019). Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science :364, 289-292.

6.Xinxin Zhang#, Yilong Yao#, Jinghua Han, Yalan Yang, Yun Chen, ZhongLin Tang*, Fei Gao*, Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development. Journal of Genetics and Genomics. 2020, 47 (8): 465-476.

7.YongSheng Zhang, YiLong Yao, ZiShuai Wang, Dan Lu, YuanYuan Zhang, Adeyinka Abiola Adetula, SiYuan Liu, Min Zhu, YaLan Yang, XinHao Fan, MuYa Chen, YiJie Tang, Yun Chen, YuWen Liu, GuoQiang Yi, ZhongLin Tang*. MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration. Genes & Diseases. 2020, https://doi.org/10.1016/j.gendis.2020.11.018.

8.Guoming Liang, Junyu Yan, Jin Guo, Zhonglin Tang*. Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs. Animals. 2020, 10(7):1114.

9.Zhang yongsheng, Lu dan, Liu Yuwen, Yi guoqiang, Tang zhonglin*. The untold story between enhancers and skeletal muscle development. Journal of Integrative Agriculture. 2020, 19(0):2-14.

10.Zishuai Wang, YalanYang, Shuaicheng Li, Kui Li, Zhonglin Tang*. Analysis and Comparison of Long Non-coding RNAs Expressed in the Ovaries of Meishan and Yorkshire pigs. Animal Genetics. 2019, 50(6):660-669.

11.Muya Chen, Yi Long Yao, Yalan Yang, Min Zhu, Yijie Tang, Siyuan Liu, Kui Li and Zhonglin Tang*. Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs. Frontiers in Genetics. 2019,10:756.

12.Zishuai Wang, Xikang Feng, Zhonglin Tang*, Shuai Cheng Li *. Genome-Wide Investigation and Functional Analysis of Sus scrofa RNA Editing Sites across Eleven Tissues. Genes (Basel). 2019,30;10(5).

13. Yalan Yang, Min Zhu, Xinhao Fan, Yilong Yao, Junyu Yan,Yijie Tang, Siyuan Liu, Kui Li* and Zhonglin Tang*. Developmental atlas of the RNA editome in Sus scrofa skeletal muscle. DNA Research. 2019, 26(3):261-272.

14. Xiaofei Yu, Zishuai Wang, Hao Sun, Guanglin Niu, Kui Li and Zhonglin Tang*. Long non‐coding MEG3 is a marker for skeletal muscle development and meat production traits in pigs. Animal Genetics. 2018, 49(6):571-578.

15. Guoming Liang, Yalan Yang, Hua Li, Hui Yu, Xunbi Li, Zhonglin Tang* and Kui Li*. LncRNAnet: a comprehensive sus scrofa lncRNA database. Animal Genetics. 2018,49(6):632-635.

16. Guoming Liang, Yalan Yang, Guanglin Niu, Zhonglin Tang*, and Kui Li*. Genome-wide profiling of Sus scrofa circular RNAs across 9 organs and 3 developmental stages, DNA Research. 2017, 24(5):523-535.

17. Zhonglin Tang*, Yang Wu*, Yalan Yang*, Yu-Cheng T. Yang, Zishuai Wang, Jiapei Yuan,Yang Yang, Chaoju Hua, Xinhao Fan, Guanglin Niu, Yubo Zhang, Zhi John Lu & Kui Li. Comprehensive analysis of long non-coding RNAs highlights their spatio-temporal expression patterns and evolutional conservation in Sus scrofa. Scientific Reports. 2017,7, 43166.

18. Yalan Yang, Guoming Liang, Guanglin Niu, Yuanyuan Zhang, Rong Zhou, Yanfang Wang, Yulian Mu, Zhonglin Tang*, Kui Li*. Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs. Scientific Reports. 2017, 7:39883.

19. Guanglin Niu#, Yalan Yang#, YuanYuan Zhang, Chaoju Hua, Zishuai Wang, Zhonglin Tang*, Kui Li. Identifying suitable reference genes for gene expression analysis in developing skeletal muscle in pigs. Peer J. 2016, 4: e2428

20. Yalan Yang, Rong Zhou, Yulian Mu,Xinhua Hou, Zhonglin Tang*, Kui Li. Genome-wide analysis of DNA methylation in obese, lean, and miniature pig breeds. Scientific Reports. 2016;7: 30160.

21. Yalan Yang#, Zhonglin Tang#, Xinhao Fan, Kui Xu, Yulian Mu, Rong Zhou*, Kui Li*. Transcriptome analysis revealed chimeric RNAs, single nucleotide polymorphisms and allele-specific expression in porcine prenatal skeletal muscle. Scientific Reports. 2016; 6:29039.

22. Chaoju Hua#, Zishuai Wang#, Jianbing Zhang, Xing Peng, Xinhua Hou, Yalan Yang, Kui Li, Zhonglin Tang*. SMAD7, antagonist of TGF-beta signaling, is a candidate of prenatal skeletal muscle development and weaning weight in pigs, Molecular Biology Reports. 2016 ,43(4):241-51.

23. Xinhua Hou#, Yalan Yang#, Shiyun Zhu, Chaoju Hua, Rong Zhou, Yulian Mu, Zhonglin Tang*, Kui Li. Comparison of skeletal muscle miRNA and mRNA profiles among three pig breeds. Molecular Genetics and Genomics. 2016,291(2):559-73.

24. Zhang L, Huang Y, Wang M, Guo Y, Liang J, Yang X, Qi W, Wu Y, Si J, Zhu S, Li Z, Li R, Shi C, Wang S, Zhang Q, Tang Zhonglin, Wang L, Li K, Fei JF, Lan G*. Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease. iScience. 2019 Jul 20;19:162-176.

招生专业

所属专业： 生物化学与分子生物学  、 畜牧

联系方式

邮箱 : tangzhonglin@caas.cn