高飞课题组

Gao Fei Lab

　　课题组长

　　高飞，研究员，博士生导师，农业部农业基因数据分析重点实验室副主任，中国遗传学会表观遗传专业委员会和中国实验动物学会无菌动物学会委员。长期从事发育和疾病过程的表观遗传控制；营养与菌群的表观遗传效应等研究。在国际SCI学术期刊Genome Biology、Cell Research等发表论文51篇，其中第一或通讯作者论文34篇。

 

　　工作经历

　　2015.04–至今        中国农业科学院农业基因组研究所  团队首席                            

      2014.10-2015.03   哥本哈根大学                                 博士后         

　　2011.02-2014.08  华大基因科技有限公司                   团队首席      

　　2004.02-2011.12  吉林大学                                       讲师          

 

　　教育经历：

　　2008.01-2010.12       奥胡斯大学                         博士       

　　2004.09-2007.07      中国科学院北京基因组所     硕士         

　　1999.09-2004.07       解放军军需大学                  学士        

 

　　研究方向：动物表观基因组学新方法开发，营养与菌群的表观遗传效应，动物发育和疾病过程的表观遗传调控。

 

　　研究成绩：运用针对微量细胞的全基因组甲基化测序技术，团队首次揭示了灵长类哺乳动物早期胚胎发育的精细DNA甲基化图谱表观遗传学调控机制；与哥本哈根大学及四川农业大学紧密合作，运用多组学手段论证了营养、抗生素（肠道菌群）对仔猪肠道DNA甲基化及仔猪肠道组织免疫与代谢功能基因的影响，进一步揭示早期肠道喂养会刺激肠道基因甲基化重塑，使肠道快速适应环境。先后在Cell Research、Genome Biology、DNA Research、Journal of Nutritional Biochemistry、Frontiers in Immunology等国际期刊发表一系列成果.　　

　　

　    Animal Epigenomics Innovation Team

　　 Chief Scientist：Fei Gao

　　Fei Gao, Principle Investigator, Doctoral Advisor, deputy director of the Key Laboratory of Agricultural Genetic Data Analysis, Ministry of Agriculture, Young talent of the Chinese Academy of Agricultural Sciences, Leading Talent of Shenzhen, member of the Professional Committee of Epigenetics, Genetics Society of China and member of the Aseptic Animal Society, Chinese Association for Laboratory Animal Sciences.

　　Research in Gao Lab focuses on the role of epigenetics in animal development and pathology, especially how environmental factors such as nutrition and microbiota may affect host epigenetics. He has published 51 peer-reviewed papers on international journals including Genome Biology, Cell Research, etc., 34 of which as the first or corresponding author.

 

　　Working Experience

　　Agricultural Genomics Institute at Shenzhen-CAAS                 

　　Principle Investigator                                       2015.04–Present

　　University of Copenhagen        

　　Postdoctoral Fellow                                          2014.10-2015.03

　　BGI      

　　Leader of Epigenetics Group                            2011.02-2014.08

　　University of Jilin                                 

　　Lecturer                                                             2004.02-2011.12

　　

　　Education

　　Aarhus University                                                                  Ph.D                   2008.01-2010.12

　　Beijing Genomics Institute, Chinese Academy of Science    Master               2004.09-2007.07

　　Quartermaster University of PLA                                          Bachelor             1999.09-2004.07

　　　

　　Research Field:

　　1) Development of new methodologies of animal epigenomics,

　　2) Effects of nutrition and microflora on animal epigenome, and

　　3) epigenetic regulation of animal development and pathology.

 

　　Achievements:

　　We have developed a novel whole-genome bisulfite sequencing technology specifically designed for the minute amount of DNA sample, and obtained single-base resolution DNA methylomes of early stages of primate embryos with this technique. In collaboration with Copenhagen University and Sichuan Agricultural University, we validated the effects of nutrition and gut microbiota on DNA methylation and the function of immune and metabolic genes in intestinal tissue of weaned piglets through a multi-omics approach, revealing that early feeding may be important to stimulate the methylation reprogramming of intestinal genes, allowing rapid intestinal adaptation. These work have been published on Cell Research, Genome Biology, DNA Research, Journal of Nutritional Biochemistry, Frontiers in Immunology etc.

　　

　　Selected publications

　　1. Hu Q, Liu C, Zhang D, Wang R, Qin L, Xu Q, Che L, Gao F. Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets. Fronties in Immunology. 2020 Jun 10;11:903. doi: 10.3389/fimmu.2020.00903.　　

　　2. Pan X, Thymann T, Gao F, Sangild PT. Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs. Fronties in Immunology. 2020 Apr 15;11:565. doi: 10.3389/fimmu.2020.00565.　　

　　3. Pan X, Zhang D, Nguyen DN, Wei W, Yu X, Gao F, Sangild PT. Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs. Fronties in Immunology. 2020 Mar 19;11:420. doi: 10.3389/fimmu.2020.00420.　　

　　4. Zhang D, Hu Q, Liu X, Zou K, Sarkodie EK, Liu X, Gao F. AllEnricher: a comprehensive gene set function enrichment tool for both model and non-model species. BMC Bioinformatics. 2020 Mar 17;21(1):106. doi: 10.1186/s12859-020-3408-y.

　　5. Lianqiang Che, Qi Hu, Ru Wang, Du Zhang, Cong Liu, Yihe Zhang, Guizhong Xin, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Daiwen Chen, De Wu, Fei Gao. Inter-correlated gut microbiota and SCFAs changes upon antibiotics exposure links with rapid body-mass gain in weaned piglet model. Journal of Nutritional Biochemistry 74 (2019) 108246

　　6. X. Pan, D. Gong, F. Gao* & P. T. Sangild*, Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics. 2018 Apr 1;10(4):395-408

　　7. Pan X, Gong D, Nguyen DN, Zhang X, Hu Q, Lu H, Fredholm M, Sangild PT, Gao F. Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. DNA Research 2018, 0(0), 1–10.

　　8.F. Gao, Y. Niu, Y. Eve Sun, H. Lu, Y. Chen, S. Li, Y. Kang, Y. Luo, C. Si, J. Yu, C. Li, N. Sun, W. Si, H. Wang, W. Ji, T. Tan, De novo DNA methylation during monkey pre-implantation embryogenesis, Cell Research (2017) :1-14.

　　

　　

　　高飞课题组更新于2021年3月